| Challenges | Approaches |
|---|
| Innovative compounds and their validated supply |
- exploiting myxobacteria by biodiversity screens and new isolation techniques
- biosynthetic engineering
- innovative chemical synthesis / mutasynthesis of compounds and simplyfied analogs
|
| Biological profiling and target identification |
- functional cellular assays based on cell motility, inflammation and apoptosis
- 3D tumor cell culture system and in vivo models
- identification and validation of novel targets
|
| In depth pharmacology |
- characterization of novel pharmacological effects and the role of respective known targets of compounds
- characterization of the signaling pathway of action in vitro
- impact of novel targets in the biological profile of compounds
|
